BTLA/HVEM (Biotiny) Inhibitor Screening Assay Kit

Intended Use

BTLA/HVEM Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of BTLA/HVEM signaling.

Contents of Kit

1. HVEM, Biotin-labeled: 10 μg, -80°C;
2. BTLA: 10 μg, -80°C;
3. Streptavidin-HRP: 15 μl, +4°C;
4. 3x BTLA Assay Buffer: 50 ml, -20°C ;
5. Blocking Buffer: 50 ml, +4°C;
6. HRP chemiluminescent substrate A (transparent bottle): 6 ml, +4°C;
7. HRP chemiluminescent substrate B (brown bottle): 6 ml, +4°C;
8. White 96-well microplate: 1, +4°C.

Storage

One year from date of receipt when stored as directed.

General Description

The binding of BTLA to the HVEM receptor (herpesvirus entry mediator, also known as TNFRSF14) triggers cell signaling pathways involved in the negative regulation of T cells. BTLA:HVEM interaction plays a key role in the regulation of inflammatory, autoimmune, and antitumor responses, and is an important target for drug discovery.