The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Function
DNA binding; chromatin binding; zinc ion binding;
Synonyms
PHF21A; PHD finger protein 21A; BHC80; BM-006; BHC80a; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80;
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