Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.
Keywords
Influenza A H5N1 (Avian) Nonstructural Protein 2 (NS2); Avian Influenza A Nonstructural 2; Influenza A H5N1 (Avian) NS2; Group V; Orthomyxoviridae; Influenzavirus A
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