This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment.
Function
DNA binding;
Synonyms
ATOH7; atonal homolog 7 (Drosophila); protein atonal homolog 7; helix-loop-helix protein mATH-5; Math5; bHLHa13;
Citations
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