Anti-eIF5A (aa 1-104) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 1-104 of Human eIF5A.

Conjugate

Application Notes

IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000; WB: 1/500 - 1/3000.

Alternative Names

EIF5A; eukaryotic translation initiation factor 5A; eukaryotic translation initiation factor 5A-1; EIF 5A; EIF5A1; MGC99547; MGC104255; eIF-4D; eIF-5A1; eIF-5A-1; rev-binding factor; eukaryotic initiation factor 5A; EIF-5A; eIF5AI;

Entrez Gene ID

UniProt ID

Antigen Description

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Pathway

Hypusine synthesis from eIF5A-lysine; Metabolism of proteins; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation; Post-translational protein modification; Translation Factors;