Specifications
Species Reactivity
Mouse; Rat; Cow; Human; African green monkey
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human eIF4A1.
Applications
Application Notes
WB: 1 μg/ml; ICC/IF: 1 μg/ml; IHC-P: 1/100.
Target
Alternative Names
EIF4A1; eukaryotic translation initiation factor 4A1; EIF4A, eukaryotic translation initiation factor 4A, isoform 1; eukaryotic initiation factor 4A-I; DDX2A; EIF 4A; eukaryotic initiation factor 4AI; ATP-dependent RNA helicase eIF4A-1; eukaryotic transla
Product Background
Antigen Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; Antiviral mechanism by IFN-stimulated genes; Cap-dependent Translation Initiation; Cytokine Signaling in Immune system; Deadenylation of mRNA; Deadenyl
Citations
Publication ()
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COA
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