Anti-ZNF382 polyclonal antibody (DPABH-16362)

Rabbit anti-Human ZNF382 (aa 1-50) polyclonal antibody for WB, ELISA

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide: MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM, corresponding to N terminal amino acids 1-50 of Human ZNF382
Conjugate
Unconjugated

Applications


Application Notes
WB: 1.25 μg/ml; Peptide ELISA: 1/1562500;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ZNF382; zinc finger protein 382; KS1; KRAB/zinc finger suppressor protein 1; multiple zinc finger and krueppel-associated box protein KS1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ZNF382 (Zinc Finger Protein 382) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF248. This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
ZNF382 is a member of the C2H2 zinc finger transcription factor family, which plays key roles in the regulation of cell proliferation, differentiation, and apoptosis in response to a variety of stimuli. Functions as a sequence-specific transcriptional repressor. The function about ZNF382 antigen include DNA binding; metal ion binding.
Pathway
Gene Expression.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Cheng, YD; Geng, H; et al. KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas. CANCER RESEARCH 70:6516-6526(2010).
Kuang, SQ; Tong, WG; et al. Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. LEUKEMIA 22:1529-1538(2008).

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