Anti-ZMAT3 monoclonal antibody (DCABH-14064) Made to order

Rabbit anti-Human ZMAT3 monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ZMAT3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ZMAT3; zinc finger, matrin-type 3; zinc finger matrin-type protein 3; FLJ12296; MGC10613; PAG608
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ZMAT3 (Zinc Finger Matrin-Type 3) is a Protein Coding gene. Among its related pathways are p53 signaling pathway. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid.
Antigen Description
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. The function about ZMAT3 antigen include RNA binding; metal ion binding; zinc ion binding.
Pathway
p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem.

Citations


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References


Rustemeyer, SM; Lamberson, WR; et al. Effects of dietary aflatoxin on the hepatic expression of apoptosis genes in growing barrows. JOURNAL OF ANIMAL SCIENCE 89:916-925(2011).

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