Anti-ZBTB24 polyclonal antibody (DPABH-27197)

Goat anti-Human ZBTB24 (aa 232-245) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide: PVEKDENYDPKTED by a Cysteine residue linker, corresponding to internal sequence amino acids 232-245 of Human ZBT24 (NP_055612.2; NP_001157785.1).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 3 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ZBTB24; zinc finger and BTB domain containing 24; BIF1; ICF2; PATZ2; ZNF450
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ZBTB24 (Zinc Finger And BTB Domain Containing 24) is a Protein Coding gene. Diseases associated with ZBTB24 include immunodeficiency-centromeric instability-facial anomalies syndrome-2 and immunodeficiency, centromere instability and facial anomalies syndrome. An important paralog of this gene is ZNF131. This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro.
Antigen Description
May be involved in BMP2-induced transcription. Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) [MIM:614069]: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about ZBTB24 antigen include DNA binding; metal ion binding; protein binding.

Citations


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References


Hammad, SM; Twal, WO; et al. Oxidized LDL immune complexes and oxidized LDL differentially affect the expression of genes involved with inflammation and survival in human U937 monocytic cells. ATHEROSCLEROSIS 202:394-404(2009).

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