General Notes
This product (Catalog No. DPABH-08461) is a rabbit-derived polyclonal antibody raised against human YME1L1, targeting the amino acid region 40–239 of the protein. This antibody exhibits cross-reactivity with Human YME1L1 from mouse. It has been affinity purified by Protein A. YME1L1(ATP-dependent zinc metalloprotease) is also named as FTSH1, YME1L,Meg-4,PAMP. YME1L1 plays a phylogenetically conserved role in mitochondrial protein metabolism.It also ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. YME1L1 can prevent mitochondrial DNA inserting into nuclear. It has 3 isoforms produced by alternative splicing with the molecular weight of 86 kDa, 80 kDa and 76 kDa. This protein can migrate with a molecular weight of about 55-63 kDa, which is the size of the mature YME1L1 protein(PMID:22252130; 22354088).
DPABH-08461 is suitable for use in Western blot (WB) (1:500–1:1,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-08461 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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