Anti-XDH monoclonal antibody, clone FQS5716

Name: Anti-XDH monoclonal antibody, clone FQS5716
SKU: DCABH-191
Rating: 5 (1 reviews)

Rabbit anti-Human XDH monoclonal antibody for WB, IHC-P

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

FQS5716

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (internal sequence)

Conjugate

Unconjugated

Applications

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250.

Target

Alternative Names

XDH; xanthine dehydrogenase; xanthene dehydrogenase; xanthine dehydrogenase/oxidase; XO; XOR; xanthine oxidase; xanthine oxidoreductase;

Entrez Gene ID

7498

UniProt ID

P47989

Product Background

Antigen Description

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

Pathway

Caffeine metabolism, organism-specific biosystem; Caffeine metabolism, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Biotransformation of adenine and cytokinins by the rhizobacterium Serratia proteamaculans

PHYTOCHEMISTRY

Authors: Taylor, Janet L.; Zaharia, L. Irina; Chen, Hao; Anderson, Erica; Abrams, Suzanne R.

Abstract

Approximately 60,000 microorganisms from Saskatchewan soil were screened for growth on the cytokinin N-6-benzyladenine (BA) as C source. A single isolate, identified as Serratia proteamaculans, grew well on BA. The culture filtrates from S. proteamaculans were screened using reversed phase high performance liquid chromatography (RP-HPLC) for the presence of secondary metabolites. The analysis revealed a major metabolite and its chemical structure was deduced as 8-hydroxy-N-6-benzyladenine (8-OHBA). Subsequently, the S. proteamaculans isolate was also found to metabolize N-6-(2-isopentenyl)adenine and adenine through oxidation of C-8 of the purine ring. A clone of the S. proteamaculans xanthine dehydrogenase (Xdh, EC 1.1.1.204) encoding genes was isolated in Escherichia coli. This E. coli isolate metabolized BA to 8-OHBA. Similar to other bacterial Xdh, the S. proteamaculans enzyme was composed of two subunits. The derived amino acid sequences of these Xdh subunits were most similar (XdhA, 60%; XdhB, 72%) to those of Pseudomonas aeruginosa. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.

Microbial and Enzymatic Process for Xylitol Production from D-glucose

CURRENT ORGANIC CHEMISTRY

Authors: Qi, Xianghui; Wang, Xu; Lin, Jing; Zhu, Jingfei; Luo, Yan; Deng, Wenying; Wang, Fei; Sun, Wenjing; Meng, Jianzong

Abstract

A microbial and enzymatic process for xylitol production that initiates from D-glucose occurs by virtue of a three-step process in which D-arabitol is the first intermediate product and D-xylulose is the second. To date, the steps of the formation of D-arabitol and the conversion of xylitol from D-xylulose are key points of departure for promoting the overall process for xylitol production from D-glucose. This review provides comprehensive insights regarding potential methods of xylitol production from D-glucose, which might be an alternative to the classical process that utilizes D-xylose as substrate.