Anti-XCL1 polyclonal antibody [Biotin]

Name: Anti-XCL1 polyclonal antibody [Biotin]
SKU: DPABY-410
Rating: 5 (1 reviews)

Goat Anti-Mouse XCL1 polyclonal antibody for WB, IHC, ELISA(Det)

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

E. coli-derived recombinant mouse XCL1/Lymphotactin

Conjugate

Biotin

Applications

Application Notes

Western Blot: 0.1 μg/mL; Immunohistochemistry: 5-15 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4173 - DPABY-410

Target

Alternative Names

XCL1; chemokine (C motif) ligand 1; LTN; ATAC; Lptn; SCM-1; Scyc1; SCM-1a; AI661682; lymphotactin; lymphotaxin; cytokine SCM-1; c motif chemokine 1; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin);

Entrez Gene ID

16963

UniProt ID

P47993

Product Background

Antigen Description

Lymphotactin (Lptn), also known as SCM-1a and ATAC, belongs to the C or gamma subfamily of chemokines and has been designated XCL1. Human Lymphotactin encodes a 114 amino acid (aa) precursor with a 21 aa predicted signal peptide. The gene for lymphotactin has been mapped to chromosome 1 in both human and mouse.

Pathway

Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; Gastrin-CREB signalling pathway

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

QUENCHED RANDOM STRAIN FIELDS AND LATTICE MEDIATED INTERACTIONS IN K(CN)XBR1-X AND K(CN)XCL1-X

JOURNAL OF CHEMICAL PHYSICS

Authors: FOSSUM, JO; GARLAND, CW

Abstract

Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis

BIOTECHNOLOGY LETTERS

Authors: Zavala-Flores, Laura M.; Villatoro-Hernandez, Julio; Gamez-Escobedo, Anali; Franco-Molina, Moises; Rangel-Colmenero, Blanca R.; Villanueva-Olivo, Arnulfo; Gutierrez-Puente, Yolanda; Montes de Oca-Luna, Roberto; Valdes-Flores, Jesus; Saucedo-Cardenas, Odila

Abstract

Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.