Anti-WWP2 (aa 1-110) polyclonal antibody

Species Reactivity

Human

Immunogen

WWP2 (NP_008945, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNN

Conjugate

Alternative Names

WWP2; WW domain containing E3 ubiquitin protein ligase 2; AIP2; WWp2-like; NEDD4-like E3 ubiquitin-protein ligase WWP2; atrophin-1 interacting protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.

Pathway

Ubiquitin mediated proteolysis;