Anti-WNT4 monoclonal antibody, clone AX003

Antibody Isotype

IgG1

Clone

AX003

Conjugate

Alternative Names

WNT4; wingless-type MMTV integration site family, member 4; protein Wnt-4; WNT 4; WNT-4; SERKAL;

Entrez Gene ID

UniProt ID

Antigen Description

The evolutionarily conserved WNT (Wingless-type MMTV integration site family) signaling pathway has diverse roles in governing cell fate, proliferation, migration, polarity and death. WNT signaling controls development and is important for embryogenesis and carcinogenesis.1-3 During tumorigenesis the WNT signaling pathway has a central role, and inappropriate activation of this pathway is observed in several human cancers, including colon carcinoma, melanoma, and ovarian cancer.4 WNT4 is a secreted glycoprotein that is critical for genitourinary development, and also has a role in the pathogenesis of renal fibrosis.5 WNT4 is also involved with the regulation of cyclin D1 transcrIPPtion, the regeneration of renal tubules in acute renal failure (ARF) Its overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.6-7 Overexpression may be associated with abnormal proliferation in human breast tissue.8

Pathway

Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;