Anti-WIPI1 monoclonal antibody, clone 3E2

Antibody Isotype

IgG2a

Clone

3E2

Species Reactivity

Human

Immunogen

WIPI1 (NP_060453.2, 348 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

WIPI1; WD repeat domain, phosphoinositide interacting 1; WD repeat domain phosphoinositide-interacting protein 1; Atg18; ATG18A; FLJ10055; WIPI49; WIPI 49 kDa; WIPI-1 alpha; atg18 protein homolog; WD40 repeat protein Interacting with phosphoInositides of

Entrez Gene ID

UniProt ID

Antigen Description

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).

Pathway

Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Unfolded Protein Response, organism-specific biosystem;