Anti-WDR64 (aa 13-42) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 13-42 of Human WDR64 (NP_653226.3).

Conjugate

Application Notes

WB: 1/100 - 1/500;

Alternative Names

WDR64; WD repeat domain 64; WD repeat-containing protein 64;

Entrez Gene ID

UniProt ID

Antigen Description

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.