Anti-WDR48 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human WDR48 is used for rabbit immunization.

Conjugate

Alternative Names

WDR48; WD repeat domain 48; P80; UAF1; WD repeat-containing protein 48; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein;

Entrez Gene ID

UniProt ID

Antigen Description

WDR48 (WD repeat domain 48) is a protein-coding gene. Diseases associated with WDR48 include inflammatory myofibroblastic tumor, and anaplastic large cell lymphoma. GO annotations related to this gene include protein binding. An important paralog of this gene is WDR83. Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Pathway

Fanconi anemia pathway;