Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide corresponding to residues in Human Tryptophanyl tRNA synthetase.
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/500 - 1/1000; Flow Cyt: 1/10 - 1/100;
Target
Alternative Names
WARS; tryptophanyl-tRNA synthetase; IFI53; tryptophan--tRNA ligase, cytoplasmic; IFP53; tryptophan tRNA ligase 1; cytoplasmic; hWRS; trpRS; interferon-induced protein 53; tryptophan tRNA ligase 1, cytoplasmic; GAMMA-2;
Product Background
Antigen Description
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Pathway
Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem;
Citations
Publication ()
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