Specifications
Immunogen
Recombinant protein corresponding to amino acids 845-949 of human VWF.
Applications
Application Notes
Immunofluorescence (1:100-1:200); Immunohistochemistry (1:100-1:200 for 30 min at RT); Immunoprecipitation (1-2 ug/500 ug protein); WB (1:200-1:400); The optimal working dilution should be determined by the end user.
Target
Alternative Names
VWF; von Willebrand factor; F8VWF; coagulation factor VIII VWF; VWD;
Product Background
Antigen Description
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrands disease. An unprocessed pseudogene has been found on chromosome 22.
Pathway
Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem;
Citations
Publication ()
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