Recombinant fragment corresponding to Human VTA1 aa 30-207. BC005937Sequence: RDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEA ITQEIVGCAH LENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENV KHRKYARWKA TYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAASLPTQPTQPSSSSTY DP
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/100 - 1/500; WB: 1/200 - 1/1000.
Target
Alternative Names
VTA1; Vps20-associated 1 homolog (S. cerevisiae); C6orf55, chromosome 6 open reading frame 55; vacuolar protein sorting-associated protein VTA1 homolog; HSPC228; My012; SKD1-binding protein 1; LYST-interacting protein 5; dopamine-responsive gene 1 protein
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Pathway
Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane Trafficking.
Citations
Publication ()
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