Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Clearance of Nuclear Envelope Membranes from Chromatin; Initiation of Nuclear Envelope Reformation; M Phase; Mitotic Anaphase; Mitotic Metaphase and Anaphase; Mitotic Prophase;
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