Anti-VAMP2 monoclonal antibody, clone 4F6

Antibody Isotype

IgG1

Clone

4F6

Species Reactivity

Human; Rat

Immunogen

Recombinant protein corresponding to amino acids 1-89 of human VAMP2.

Conjugate

Application Notes

WB (1:2000-1:3000) & The optimal working dilution should be determined by the end user.

Alternative Names

VAMP2; vesicle-associated membrane protein 2 (synaptobrevin 2); SYB2; vesicle-associated membrane protein 2; VAMP 2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; VAMP-2; FLJ11460;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

Pathway

Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem; BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin, organism-specific biosystem; Botulinum neurotoxicity, organism-specific biosystem; Clathrin derived vesicle budding, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Dopamine Neurotransmitter Release Cycle, organism-specific biosystem;