General Notes
This product (Catalog No. DPABH-13245) is a rabbit-derived polyclonal antibody raised against human UTP11L, targeting the amino acid region 1–253 of the protein. It has been affinity purified by Protein A. UTP11L is a nucleolar protein and a key component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It primarily participates in the processing of ribosomal RNA (rRNA) precursors, playing a critical role in the maturation of 18S rRNA and the assembly of the 40S small ribosomal subunit. As a core regulator of ribosome biogenesis, UTP11L maintains the stability of the rRNA processing complex by interacting with other members of the UTP protein complex. Studies have shown that dysregulation of UTP11L expression is closely associated with abnormal cell proliferation. Its upregulation has been observed in various tumors, such as hepatocellular carcinoma, and may promote tumor progression by affecting ribosome production. Currently, UTP11L is considered a potential tumor biomarker, and the specific molecular mechanisms by which it functions in ribosome biogenesis remain an important focus in cell biology research.
DPABH-13245 is suitable for use in Western blot (WB) (1:1,000–1:6,000) application.
DPABH-13245 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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