Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human USP9Y aa 2500 to the C-terminus. The exact sequence is proprietary.Database link: O00507
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/200;
Target
Alternative Names
USP9Y; ubiquitin specific peptidase 9, Y-linked; ubiquitin specific peptidase 9, Y linked (fat facets like, Drosophila); probable ubiquitin carboxyl-terminal hydrolase FAF-Y; DFFRY; fat facets like homolog (Drosophila); ubiquitin thioesterase FAF-Y; deubi
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling.
Citations
Publication ()
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