Anti-USP20 (aa 252-349) polyclonal antibody

Species Reactivity

Human

Immunogen

USP20 (NP_001008563, 252 a.a. ~ 349 a.a) partial recombinant protein with GST tag. The sequence is VATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSQAETEL LIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD

Conjugate

Alternative Names

USP20; ubiquitin specific peptidase 20; VDU2; hVDU2; LSFR3A; ubiquitin carboxyl-terminal hydrolase 20; ubiquitin thioesterase 20; deubiquitinating enzyme 20; ubiquitin thiolesterase 20; ubiquitin-specific-processing protease 20; pVHL-interacting deubiquit

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.