Synthetic peptide, corresponding to a region within amino acids 433-483 (NKDRPAMQLY QPGARSRNRL CPPDDSTKSG DSAAERKQES GISHRKEGGE E) of Human UPF3B/RENT3B (NP_542199.1).
UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. UPF3B binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X (referenced from entrez gene).
Pathway
Cleavage of Growing Transcript in the Termination Region; Exon junction complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Capped Intron-Containing Pre-mRNA
Citations
Publication ()
Have you cited DPABH-25688 in a publication? Let us know and earn a reward for your research.
My Review for Anti-UPF3B (aa 433-483) polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
