Anti-UGT1A8 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human UGT1A8 is used for rabbit immunization.

Conjugate

Alternative Names

UGT1A8; UDP glucuronosyltransferase 1 family, polypeptide A8; UDPGT; UGT1H; UGT-1H; UGT1.8; UGT1-08; UGT1A8S; UDPGT 1-8; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A8; UDP glycosyltransferase 1 family, p

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.

Pathway

Ascorbate and aldarate metabolism; Biological oxidations; Chemical carcinogenesis; Drug metabolism - cytochrome P450; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Fatty acid, triacylglycerol, and ketone body metabolism; Glucuronidation; Heme degradation; Metabolism; Metabolism of lipids and lipoproteins;