Anti-UGT1A6 (aa 44-143) polyclonal antibody

Species Reactivity

Human

Immunogen

UGT1A6 (NP_001063, 44 a.a. ~ 143 a.a) partial recombinant protein with GST tag. The sequence is DIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERS FLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESK

Conjugate

Alternative Names

UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; GNT1; UGT1; HLUGP; UDPGT; UGT1F; HLUGP1; UGT1A6S; UDPGT 1-6; UDP-glucuronosyltransferase 1-6; UGT-1F; UGT1*6; UGT1.6; UGT1-06; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.

Pathway

AhR pathway; Ascorbate and aldarate metabolism; Chemical carcinogenesis; Drug metabolism - cytochrome P450