Anti-UBA52 (aa 29-128) polyclonal antibody

Species Reactivity

Human

Immunogen

UBA52 (NP_003324, 29 a.a. ~ 128 a.a) partial recombinant protein with GST tag. The sequence is KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQK YNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK

Conjugate

Alternative Names

UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1; L40; CEP52; RPL40; HUBCEP52; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; 60S ribosomal protein L40; ubiquitin-52 amino acid fusion protein; ubiquitin carboxyl extension protein 52

Entrez Gene ID

UniProt ID

Antigen Description

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.

Pathway

APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc2 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Activated NOTCH1 Transmits Signal to the Nucleus.