Specifications
Immunogen
Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.
Applications
Application Notes
Flow Cyt: Neat - 1/10
Target
Alternative Names
Timd2; T cell immunoglobulin and mucin domain containing 2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662; T-cell immunoglobulin and mucin domain-containing protein 2; TIMD-2; T-cell membrane protein 2; T-cell immunoglobulin mucin receptor 2; T-
Product Background
Antigen Description
Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.Studies usingRat anti Mouse TIM-2 antibody, clone SNU3-36 in mouse, have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, during early phase CIA (collagen-induced arthritis).
Citations
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Tinari, N; DEgidio, M; et al. Identification of the tumor antigen 90K domains recognized by monoclonal antibodies SP2 and L3 and preparation and characterization of novel anti-90K monoclonal antibodies. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 232:367-372(1997).
Miyanishi, M; Tada, K; et al. Identification of Tim4 as a phosphatidylserine receptor. NATURE 450:435-439(2007).
COA
Certificate of Analysis![Mouse Anti-Mouse TIMD2 Chimeric Monoclonal Antibody, clone RMT2-14 [Functional Grade] (CABT-Z485M)](https://img2.creative-diagnostics.com/productimage/CABT-Z485M_1.jpg)
