Anti-TLN1 monoclonal antibody, clone Ubm-44

Antibody Isotype

IgG1

Clone

Ubm-44

Species Reactivity

Chicken

Immunogen

Full length native protein (purified) corresponding to Chicken Talin 1 and 2. Chicken gizzard talin.

Conjugate

Alternative Names

TLN1; talin 1; talin-1; Tln;

Entrez Gene ID

UniProt ID

Antigen Description

Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Talin 2 is related to talin 1. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.

Pathway

Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;