This product (Catalog No. DPABH-25545) is a rabbit-derived polyclonal antibody raised against human TXNRD3. This antibody exhibits cross-reactivity with Human TXNRD3 from mouse and rat. It has been affinity purified by Protein A. TXNRD3, also named as TGR and TRXR3, belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. TXNRD3 displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. TXNRD3 catalyzes the reaction: Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. TXNRD3 promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. DPABH-25545 is suitable for use in Western blot (WB) (1:1,000–1:4,000), IHC (1:50–1:500) applications. DPABH-25545 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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