General Notes
This product (Catalog No. DPABH-18270) is a rabbit-derived IgG polyclonal antibody raised against human TULP3, targeting the amino acid region 251–350 of the protein. This antibody exhibits cross-reactivity with TULP3 from mouse, rat, chicken, dog, and horse. It has been affinity purified by Protein A. This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
DPABH-18270 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-18270 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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