Anti-TUBB4A monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human TUBB4 is used for rabbit immunization.

Conjugate

Alternative Names

TUBB4A; tubulin, beta 4A class IVa; DYT4; TUBB4; TUBB5; beta-5; tubulin beta-4A chain; tubulin, beta, 5; tubulin beta-4 chain; dystonia 4, torsion (autosomal dominant);

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X.

Pathway

Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; Chaperonin-mediated protein folding; Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding; Formation of tubulin folding intermediates by CCT/TriC; G2/M Transition; Gap junction; Loss of Nlp from mitotic centrosomes; Loss of proteins required for interphase microtubule organization??from the centrosome; Metabolism of proteins;