Anti-TTN monoclonal antibody, clone U22

Antibody Isotype

IgG2b

Clone

U22

Species Reactivity

Chicken

Immunogen

Full length native protein (purified) (Chicken breast muscle).

Conjugate

Alternative Names

TTN; titin; titin protein homolog;

Entrez Gene ID

Antigen Description

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Pathway

Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Striated Muscle Contraction, organism-specific biosystem;