Anti-TRRAP monoclonal antibody, clone FQS25063

Antibody Isotype

IgG

Clone

FQS25063

Species Reactivity

Human

Immunogen

Recombinant fragment within Human TRRAP aa 2700-2850. The exact sequence is proprietary.Database link: Q9Y4A5

Conjugate

Application Notes

WB: 1/10000 - 1/50000; ICC/IF: 1/500;

Alternative Names

TRRAP; transformation/transcription domain-associated protein; PAF400; TR AP; Tra1; tra1 homolog; 350/400 kDa PCAF-associated factor; TR-AP; STAF40; PAF350/400; FLJ10671;

Entrez Gene ID

UniProt ID

Antigen Description

TRRAP (TRansformation/tRanscription domain Associated Protein) is an adapter protein that is found in a number of multiprotein chromatin complexes with histone acetyltransferase (HAT) activity. These complexes include PCAF, TFTC-HAT, TIP60 HAT, STAGA, and BAF53 complexes. TRRAP is thought to be responsible for the concerted and context-dependent recruitment of these complexes to chromatin during transcription, replication and DNA repair. TRRAP plays a key role in transcriptional activation by c-Myc, p53/TP53, E2F1 and E2F4.

Pathway

C-MYC pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Validated targets of C-MYC transcriptional activation, organism-specific biosystem;