Anti-TRPM5 monoclonal antibody, clone FQS8615

Antibody Isotype

IgG

Clone

FQS8615

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues near the N terminus of Human TRPM5 (UniProt Q9NZQ8).

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

TRPM5; transient receptor potential cation channel, subfamily M, member 5; transient receptor potential cation channel subfamily M member 5; LTRPC5; MTR1; LTrpC-5; MLSN1 and TRP-related; MLSN1- and TRP-related gene 1 protein; long transient receptor poten

Entrez Gene ID

UniProt ID

Antigen Description

Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Pathway

Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem.