The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Pathway
Axon guidance; Developmental Biology; Effects of PIP2 hydrolysis; Elevation of cytosolic Ca2+ levels; G alpha (q) signalling events; GPCR downstream signaling; Gastrin-CREB signalling pathway via PKC and MAPK; Hemostasis
Citations
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