Anti-TRIM25 monoclonal antibody, clone FQS8426

Antibody Isotype

IgG

Clone

FQS8426

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human TRIM25 (UniProt Q14258).

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250; IP: 1/10 - 1/100;

Alternative Names

TRIM25; tripartite motif containing 25; tripartite motif containing 25 , zinc finger protein 147 (estrogen responsive finger protein) , ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; EFP; RNF147; RING finger protein 147; zinc finger protein-147; tripartite mo

Entrez Gene ID

UniProt ID

Antigen Description

Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.

Pathway

Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Innate Immune System, organism-specific biosystem;