Anti-TRF1 monoclonal antibody, clone FQS7424

Antibody Isotype

IgG

Clone

FQS7424

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide corresponding to a region within Human TRF1.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC: 1/100 - 1/250.

Alternative Names

TERF1; telomeric repeat binding factor (NIMA-interacting) 1; TRBF1; telomeric repeat-binding factor 1; PIN2; TRF; TRF1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1; t-TRF1; hTRF1-AS; FLJ41416;

Entrez Gene ID

UniProt ID

Antigen Description

Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Pathway

Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Synapsis, organism-specific biosystem; Packaging Of Telomere Ends, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem; Shelterin complex, organism-specific biosystem;