Anti-TRAF2 monoclonal antibody, clone FQS8175 Knockout Validated

Antibody Isotype

IgG

Clone

FQS8175

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to residues in Human TRAF2 (UniProt Q12933).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC/IF: 1/100 - 1/250; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100;

Alternative Names

TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012;

Entrez Gene ID

UniProt ID

Antigen Description

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.

Pathway

Activation of Pro-Caspase 8, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem;