Synthetic peptide within Human TRADD aa 133-159 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q15628
TRADD; TNFRSF1A-associated via death domain; tumor necrosis factor receptor type 1-associated DEATH domain protein; Hs.89862; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Pathway
Activation of Pro-Caspase 8; Adipocytokine signaling pathway; Apoptosis;
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