Anti-TPI1 monoclonal antibody, clone FQS23250(C)

Antibody Isotype

IgG

Clone

FQS23250(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Triosephosphate isomerase aa 250 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: P60174

Conjugate

Application Notes

WB: 1/1000 - 1/5000; Flow Cyt: 1/10 - 1/100;

Alternative Names

TPI1; triosephosphate isomerase 1; triosephosphate isomerase; triose-phosphate isomerase; TIM; TPI; MGC88108;

Entrez Gene ID

UniProt ID

Antigen Description

Triosephosphate isomerase (TIM) catalyses the reversible interconversion of G3P and DHAP. Only G3P can be used in glycolysis, therefore TIM is essential for energy production, allowing two molecules of G3P to be produced for every glucose molecule, thereby doubling the energy yield. Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

Pathway

Fatty Acid Beta Oxidation, organism-specific biosystem; Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate =>.