Specifications
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human 53BP1 aa 900-1000 (Cysteine residue). The exact sequence is proprietary.Database link: Q12888
Applications
Application Notes
WB: 1/50000 - 1/200000; IHC-P: 1/50 - 1/100; ICC/IF: 1/100 - 1/250;
Target
Alternative Names
TP53BP1; tumor protein p53 binding protein 1; tumor protein p53 binding protein, 1; tumor suppressor p53-binding protein 1; 53BP1; p202; p53BP1; p53-binding protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1; FLJ41424; MG
Product Background
Antigen Description
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
Pathway
DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem; Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem; Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystem.
Citations
Publication ()
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