Specifications
Immunogen
Recombinant fragment corresponding to Human Topoisomerase II alpha aa 1100-1531. Produced in E.coli cells (NP_001058).Sequence: EEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRN EKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGK AKGKKTQMAEVLPSPRGQRVIPRIT
Applications
Application Notes
IHC-P: 1/150; WB: 1/2000.
Target
Alternative Names
TOP2A; topoisomerase (DNA) II alpha 170kDa; TOP2, topoisomerase (DNA) II alpha (170kD); DNA topoisomerase 2-alpha; DNA gyrase; DNA topoisomerase II, 170 kD; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase II, alpha isozyme; TOP2; TP2A;
Product Background
Antigen Description
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Pathway
Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; G0 and Early G1, organism-specific biosystem; Mitotic G1-G1/S phases, organism-specific biosystem;
Citations
Publication ()
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COA
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