Anti-TNNC1 (full length) polyclonal antibody

Name: Anti-TNNC1 (full length) polyclonal antibody
SKU: DPAB-DC3086
Rating: 5 (1 reviews)

Mouse Anti-Human TNNC1 (full length) polyclonal antibody for WB, ELISA

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COA

SDS

Datasheet

Summary

Specifications

Species Reactivity

Human

Immunogen

TNNC1 (AAH30244, 1 a.a. ~ 161 a.a) full-length recombinant protein with GST tag. The sequence is MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEM IDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIM LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Conjugate

Unconjugated

Target

Alternative Names

TNNC1; troponin C type 1 (slow); TNC; TN-C; TNNC; CMD1Z; CMH13; troponin C, slow skeletal and cardiac muscles; troponin C1, slow; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C;

Entrez Gene ID

7134

UniProt ID

P63316

Product Background

Antigen Description

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

Pathway

Adrenergic signaling in cardiomyocytes; Calcium signaling pathway; Cardiac muscle contraction; Dilated cardiomyopathy

Citations

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Documents

pdf COA

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References

Identification of differentially-expressed genes in lung squamous cell carcinoma and correlation levels with prognosis through integrated bioinformatics analysis

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

Authors: Zhang, Licui; Zhong, Chen; Gu, Yang; Ma, Yajing; Ming, Xinliang; Su, Xin; Liu, Min

Abstract

Background: The aim of the current study was to screen differentially-expressed genes (DEGs) relevant to cancer progression and prognosis of squamous cell lung carcinoma (SqCLC). Methods: DEGs mRNA expression data of SqCLC was screened from the Oncomine database. This data was further analyzed by comparing tumor tissues to normal tissues. Prognostic values of DEGs relevant to SqCLC were investigated using the "Kaplan-Meier Plotter" (KM plotter) database. Bioinformation for included genes was analyzed by gene GO and KEGG enrichment, aiming to explain the potential roles of identified genes in SqCLC. Protein-protein interaction (PPI) of the genes was evaluated using the STRING database. Results: Four independent microarray datasets relevant to SqCLC were identified in the Oncomine database, with the top 10 consistently upregulated and top 10 consistently downregulated genes included in the present analysis. Significant differences of overall survival (OS) were correlated with SMC4, HIST2H2AA3, GMPS, CKS1B, POLR2H, PDCD10, PLOD2, DVL3, C-type CLEC3B, TNNC1, FAM107A, FYR, MEF2C, SLIT3, CX3CR1, C17orf91, LIM, and LIMCH1 (all P < 0.05). Possible protein-protein interaction analysis of the top 20 dysregulated genes showed that proteins of SMC4, POLR2H, and NCBP2 in upregulated genes and TNNC1 and MEF2C in downregulated genes interacted with more than 5 other proteins. This may play an important role in the development of SqCLC. Conclusion: MC4, POLR2H. TNNC1, and MEF2C genes were dysregulated in SqCLC. Thus, they may play an essential role in the development of SqCLC, as biomarkers for patient prognosis.

Mapping TNNC1, the gene that encodes cardiac troponin I in the human and the mouse

GENOMICS

Authors: Bermingham, N; Hernandez, D; Balfour, A; Gilmour, F; Martin, JE; Fisher, EMC

Abstract

We have mapped the TNNC1 gene, whose protein product is the cardiac TnI protein. TnI is one of the proteins that makes up the troponin complex, which mediates the response of muscle to calcium ions. The human TNNC1 locus had been assigned to a large region of chromosome 19, and we have refined the mapping position to the distal end of the chromosome by amplification of DNAs from a chromosome 19 mapping panel. We have also mapped the mouse Tnnc1 locus, by following the segregation of an intron sequence through DNAs from the European Interspecific Backcross. Tnnc1 maps close to the centromere on mouse chromosome 7. (C) 1995 Academic Press, Inc.