Anti-TMEM66 polyclonal antibody (DPABH-04480)

Rabbit anti-Human TMEM66 (aa 1-211) polyclonal antibody for WB, IHC-P, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 1-211 of Human TMEM66 (Uniprot ID: Q96BY9).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TMEM66; transmembrane protein 66; MGC8721; protein FOAP-7; SARAF long isoform; SARAF short isoform
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
TMEM66 (transmembrane protein 66) is a protein-coding gene. GO annotations related to this gene include protein binding and store-operated calcium channel activity. SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66). SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sincock, PM; Fitter, S; et al. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. JOURNAL OF CELL SCIENCE 112:833-844(1999).
Kemp, EH; Sandhu, HK; et al. Low Frequency of Pendrin Autoantibodies Detected Using a Radioligand Binding Assay in Patients With Autoimmune Thyroid Disease. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98:E309-E313(2013).

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