General Notes
This product (Catalog No. DPABH-28440) is a rabbit-derived polyclonal antibody raised against human TMEM164, targeting the amino acid region 1–38 of the protein. This antibody exhibits cross-reactivity with Human TMEM164 from mouse. It has been affinity purified by Protein A. TMEM164 (Transmembrane Protein 164) is a membrane protein with significant roles in various biological processes, including lipid metabolism, neuroprotection, and cancer regulation. In non-small cell lung cancer (NSCLC), TMEM164 promotes ferroptosis by mediating autophagy, leading to the degradation of ferritin, GPX4, and lipid droplets, which facilitates iron accumulation and lipid peroxidation (PMID: 39798196). In neurodegenerative diseases, TMEM164 overexpression via gene therapy shows promise in reducing neurotoxic reactive astrocyte activation and alleviating disease symptoms (PMID: 37679556).
DPABH-28440 is suitable for use in IHC (1:50–1:500), IF/ICC (1:200–1:800) applications.
DPABH-28440 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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