General Notes
This product (Catalog No. DPABH-20996) is a rabbit-derived polyclonal antibody raised against human TM7SF3, targeting the amino acid region 1–295 of the protein. This antibody exhibits cross-reactivity with Human TM7SF3 from mouse. It has been affinity purified by Protein A. The seven-transmembrane superfamily member 3 protein (TM7SF3) is a pro-survival factor induced by p53 that regulates protein homeostasis and attenuates cellular stress. TM7SF3 inhibits caspase 3/7 while siRNA-mediated silencing of TM7SF3 accelerates ER stress and the unfolded protein responses (UPR). This involves inhibitory phosphorylation of eIF2α activity and increased expression of ATF3, ATF4, and C/EBP, followed by induction of apoptosis. TM7SF3 maintains cellular reducing power within physiological levels and reduces the content of proapoptotic proteins such as FAS, FADD, and caspase-8. (PMID: 36304109).
DPABH-20996 is suitable for use in Western blot (WB) (1:500–1:3,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-20996 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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