Specifications
Immunogen
Recombinant fragment corresponding to Human TLR7 aa 562-839.
Applications
Application Notes
WB: 10 μg/ml; Flow Cyt: 1-2μg/106 cells;
Target
Alternative Names
TLR7; toll-like receptor 7;
Product Background
Antigen Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Pathway
Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Innate Immune System, organism-specific biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem; MyD88 dependent cascade initiated on endosome, organism-specific biosystem.
Citations
Publication ()
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COA
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